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Baby Diapers Case

New technique predictably generates complex, wavy shapes (MIT)

The flexible properties of hydrogels — highly absorbent, gelatinous polymers that shrink and expand depending on environmental conditions such as humidity, pH and temperature — have made them ideal for applications from contact lenses to baby diapers and adhesives. In recent years, researchers have investigated hydrogels’ potential in drug delivery, engineering them into drug-carrying vehicles that rupture when exposed to certain environmental stimuli. Such vesicles may slowly release their contents in a controlled fashion; they may even contain more than one type of drug, released at different times or under various conditions. However, it’s difficult to predict just how hydrogels will rupture, and up until now it’s been difficult to control the shape into which a hydrogel morphs. Nick Fang, an associate professor of mechanical engineering at MIT, says predicting how hydrogels transform could help in the design of more complex and effective drug-delivery systems. “What kind of shape is more efficient for flowing through the bloodstream and attaching to a cell membrane?” Fang says. “With proper knowledge of how gels swell, we can start to generate patterns at our wish.” Fang and postdoc Howon Lee, along with colleagues at Arizona State University, are studying the mechanics of ...

MIT


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